Last edited by Dulabar
Wednesday, August 12, 2020 | History

1 edition of Free-radical-induced DNA damage and its repair found in the catalog.

Free-radical-induced DNA damage and its repair

C. von Sonntag

Free-radical-induced DNA damage and its repair

a chemical perspective

by C. von Sonntag

  • 20 Want to read
  • 40 Currently reading

Published by Springer in Berlin, London .
Written in English

    Subjects:
  • DNA damage,
  • DNA repair,
  • Free radicals (Chemistry)

  • Edition Notes

    StatementClemens von Sonntag
    The Physical Object
    Pagination1 v. :
    ID Numbers
    Open LibraryOL25559736M
    ISBN 103642065546
    ISBN 109783642065545
    OCLC/WorldCa750955357

    Language: English ISBN: (alk. paper), (alk. paper) LCCN: MeSH: DNA Damage; DNA Repair; Free Radicals/adverse effects*Free Radicals/chemistry* Notes: Includes bibliographical references and index. Concrete And Its Chemical Behaviour By Eglinton, M.s. Hardback Book The Fast $ Beet-sugar Making And Its Chemical Control By Yasujuro Nikaido , Paperback.

    Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective Clemens von Sonntag New York:Springer, pp. ISBN: , $ From Cells to Proteins: Imaging Nature across Dimensions V. Evangelista, L. Barsanti, V. Passarelli, P. Gualtieri, eds. New York:Springer, pp. ISBN: , $ Fundamentals of. Sustained oxidative damage results only under conditions of oxidative stress—when the detoxifying and repair systems are insufficient. Free radical-induced damage, when left unrepaired, destroys lipids, proteins, RNA, and DNA, and can contribute to disease.

    Miscellaneous Comments Off on Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective Feb 13 Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA.   Free radicals and antioxidants 1. Free Radical Injury & Antioxidants 2. Introduction It is believed that life has originated from basic chemicals by free radical reaction, largely initialled by ionising radiation from sun. Paradoxically the same reactions creating life may also be responsible for many diseases, ageing and death. 3.


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Free-radical-induced DNA damage and its repair by C. von Sonntag Download PDF EPUB FB2

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA.

Free-radical DNA damage may lead to mutations, cancer, and cell death. The free-radical chemistry of DNA had been discussed in some detail in in my book The Chemical Basis of Radiation Biology.

Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing.

Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much. Free Radical Induced DNA Damage and Its Repair PDF Free Download E-BOOK DESCRIPTION The free-radical chemistry of DNA had been discussed in some detail in in my book The Chemical Basis of Radiation Biology.

It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair by: Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective - Kindle edition by Sonntag, Clemens.

Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Free-Radical-Induced DNA Damage and Its Repair: A Chemical : Clemens Sonntag.

Free-radical-induced DNA damage and its repair: a chemical perspective. [C von Sonntag] Home. WorldCat Home About WorldCat Help. Search. Search for The free-radical chemistry of DNA had been discussed in some detail in in my book The Chemical Basis of Radiation Biology.

Moreover. Introduction. Free radicals are produced in living cells by normal metabolism and by exogenous sources such as carcinogenic compounds and ionizing radiations (reviewed in).Of the free radicals, the highly reactive hydroxyl radical (OH) causes damage to DNA and other biological molecules (reviewed in,).This type of DNA damage is also called “oxidative damage to DNA” and is implicated in Cited by: Get this from a library.

Free-radical-induced DNA damage and its repair: a chemical perspective. [C von Sonntag] -- Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now. Free-Radical-Induced DNA Damage and Its Repair: A Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon.

It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by Price: $ It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources.

Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Free-Radical-Induced DNA Damage and Its Repair A Chemical Perspective Provides an invaluable reference tool for the study of free radical-induced DNA damage and its repair, balancing the chemical and molecular approaches Understanding of the molecular basis of.

DNA repair processes. The defences against free radical damage described above are imperfect, and in the case of DNA damage, if it is not repaired, it may become fixed by the process of DNA replication to form mutations.

DNA is the only biomolecule for which a true repair system exists. There is mounting evidence for an important role of free radical-induced DNA damage in the etiology of numerous diseases including cancer.

Further understanding of mechanisms of free radical-induced DNA damage, and cellular repair and biological consequences of DNA damage products will be of outmost importance for disease prevention and by: Background. The free radical theory of aging was conceived by Denham Harman in the s, when prevailing scientific opinion held that free radicals were too unstable to exist in biological systems.

This was also before anyone invoked free radicals as a cause of degenerative diseases. Two sources inspired Harman: 1) the rate of living theory, which holds that lifespan is an inverse function of.

Free radical damage to DNA can occur as a result of exposure to ionizing radiation or to radiomimetic compounds. Damage to DNA as a result of free radical attack is called indirect DNA damage because the radicals formed can diffuse throughout the body and affect other organs.

Malignant melanoma can be caused by indirect DNA damage because it is found in parts of the body not exposed to sunlight. Download Ebook Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective pdf Free Download medical books free Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA.

In book: Free-Radical-Induced DNA Damage and Its Repair. Free-radical-induced chain scission in hyaluronic acid in aqueous solution has been studied using pulse radiolysis.

(-1)), and the. Mechanisms of free radical-induced damage to DNA Article Literature Review (PDF Available) in Free Radical Research 46(4) January with 3, Reads How we measure 'reads'.

Abstract Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms.

The highly reactive hydroxyl radical reacts with the heterocyclic DNA bases and the sugar moiety near or at diffusion-controlled rates by addition to the double bonds and H atom-abstraction from the C H-bonds of the sugar moiety and the methyl group Cited by: Kupte si knihu Free-Radical-Induced DNA Damage and Its Repair: Sonntag, Clemens: za nejlepší cenu se slevou.

Podívejte se i na další z miliónů zahraničních knih v naší nabídce. Zasíláme rychle a levně po ČR. Bohr V () Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cell.

Free Rad Biol Med – CrossRef PubMed Google Scholar Bonifacic M, Stefanic I () Oxidation of organic sulfides by .Oxygen Radicals in Biology and Medicine by Simic, Michael G.; Taylor, Karen A.; John F. Ward, Clemens Von Sonntag and a great selection of related books, art and collectibles available now at Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective.

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